The National Institutes of Health is accepting applications for its New Epidemiological Cohort Study among Asian Americans, Native Hawaiians, and Pacific Islanders (AsA-NHPI): Coordinating Center.
Donor Name: National Institutes of Health
State: All States
County: All Counties
Territory: Commonwealth of Puerto Rico, the U.S. Virgin Islands, Guam, American Samoa, the Commonwealth of the Northern Mariana Islands
Type of Grant: Grant
Deadline: 10/13/2022
Size of the Grant: $33.3 million
Grant Duration: 7 years
Details:
Purpose
This Funding Opportunity Announcement (FOA), utilizing the U24 grant funding mechanism, invites applications for a Coordinating Center (CC) to establish a new population-based cohort study to address key population research gaps in the health of Asian Americans (AsA), Native Hawaiians, and Pacific Islanders (NHPI). This epidemiological cohort study will enable the enrollment, initial examination, and follow-up activities of a cohort of approximately 10,000 participants from multiple immigrant generations of ancestral Asians living in the United States, as well as Native Hawaiians and Pacific Islanders. Specifically, this initiative will utilize a “populomics” perspective, i.e., examination of health influences across multiple levels (biological, lifestyle/behavioral, environmental, sociocultural) using multi-disciplinary methods to investigate the web of influences impacting the health of AsA-NHPI subpopulations.
The sampling design will support two analytical objectives:
- to estimate the prevalence, mean values and distribution of key health and risk factors, with sufficient sample size to stratify by place of origin of major AsA-NHPI subpopulations and other relevant demographic characteristics that are clearly defined, consistently used and transparently presented (e.g., sex, gender, education, occupation, religiosity, income, self-identified race and ethnicity, etc.);
- to evaluate relationships among baseline risk factors, and relationships of risk factors with health outcomes. Representative samples of participants will be drawn from census tracts in these defined communities and recruited from households using strategies that maximize participation rates, and minimize nonresponse and attrition during follow-up.
Specific Areas of Research
Core questions that are expected to be addressed through the baseline exam include the following:
- How do cardiovascular and lung health in first- and subsequent-generation immigrants differ from comparable cohorts in their countries of origin?
- How do generational and neighborhood exposures impact health outcomes, including sleep quality, mental health, cardiopulmonary, and cognition among AsA-NHPI subpopulations?
- What is the interrelationship between acculturation, discrimination, neighborhood factors, social networks and kinship structures and how do these factors intersect to impact health outcomes?
- What is the relationship between sociocultural, environmental, behavioral, clinical and/or genetic risk factors with metabolic disorders (e.g., glucose intolerance, dyslipidemia) in AsA-NHPI subpopulations?
- What are the health effects of tobacco and nicotine delivery products across populations and the potential impacts on incidence of pulmonary disease and cardiovascular diseases?
- Why is there a need to develop and validate acculturation instruments for AsA-NHPI subpopulations that include items beyond those that are language-based?
- How do protective factors, such as resilience or social support, contribute to health in AsA-NHPI subpopulations, including how such protective factors may differ across immigrant groups and/or generations?
- What is the prevalence and incidence of neurological disease (e.g., stroke, dementia, cognitive impairment, multiple sclerosis, epilepsy, traumatic brain injury, pain syndromes, etc.) in the AsA-NHPI subpopulations?
- What are the independent and combined contributions of genetics and other risk factors (e.g., clinical, family history, environmental, social determinants of health) to the incidence of diseases most severely impacting AsA-NHPI?
- What is the interrelationship between acculturation, discrimination, neighborhood factors, social networks and kinship structures and how do these factors intersect to impact health outcomes?
Funding Information
- NHLBI intends to fund one award for this U24, corresponding to total costs of up to $2.2 million in Fiscal Year (FY) 2023, $3.6 million in FY 2024, $6.7 million in FY 2025, $6.7 million in FY 2026, $6.7 million in FY 2027, $4.0 million in FY 2028, and $3.4 million in FY 2029 for a total contribution of $33.3 million for 7 years.
- The maximum project period of award is expected to be 7 years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Government
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations.
For more information, visit Grants.gov.