This Funding Opportunity Announcement (FOA) allows for renewal and competing revision applications, and their resubmissions, for funded U54 Specialized Center cooperative agreements that support large-scale, complex research projects with multiple highly integrated components focused on a common research question relevant to Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD).
Donor Name: National Institute on Aging (NIA)
Country: U.S.
Territory: American Samoa, Guam, Northern Mariana Islands, Puerto Rico, and U.S. Virgin Islands
State: All States
Type of Grant: Grant
Deadline (mm/dd/yyyy): 10/17/2024
Grant Duration: 5 years
Details:
It is anticipated that such projects will likely involve an integrated multidisciplinary team of investigators within a single institution or a consortium of institutions, and will address one or more AD/ADRD implementation research milestones supporting the research goals of the National Plan to Address Alzheimer’s and Related Dementias.
This FOA allows for renewal and competing revision applications for awarded U54 Specialized Center applications focused on a common research question relevant to AD/ADRD. Such projects will likely involve an integrated multidisciplinary team of investigators within a single institution or a consortium of institutions. Resources and study expertise will be tightly coordinated across multiple sites or cores, such as:
- One or more coordinating centers.
- Clinical or study sites.
- Specialized cores, such as for data management and analysis, measurement and phenotyping, animal models, etc.
- Specialized Projects, including, but not limited to, the following: development of new animal models of AD/ADRD; the enablement and experimental validation of next generation AD/ADRD drug targets for the purposes of drug discovery and/or elucidation of AD/ADRD biology; development of large-scale AD/ADRD data infrastructure; and identification of targets and refinement of new non-pharmacological AD/ADRD prevention and dementia care interventions.
Specific areas of research interest include, but are not limited to:
- Development of data infrastructure and platforms for AD/ADRD clinical trials and observational research through integration of multiple data sources.
- Collaborative research within and among health and long-term care systems to encourage pragmatic trials of innovative dementia care.
- Translation of basic science findings into pre-clinical or clinical studies, or of clinical findings into practice or community settings, for prevention, diagnosis, or treatment of AD/ADRD conditions, and/or care of persons living with dementia, requiring coordination of broad multidisciplinary expertise across multiple settings.
- Development of next generation animal models of AD; extensive characterization and clinicopathological staging of AD animal models using translatable biomarkers; development of translatable pharmacodynamic biomarkers for novel therapeutic targets; and rigorous preclinical testing of candidate AD therapeutics.
- Development of computational and experimental target enabling tools; characterization and experimental validation of candidate AD/ADRD drug targets; and advancing novel targets into drug discovery and preclinical drug development for the purpose of diversifying and reinvigorating the AD/ADRD drug development pipeline.
- Development, facilitation, and support of AD genetic activities for all phases of the Alzheimer’s Disease Sequencing Project (ADSP) such as quality control checking, data harmonization, and meta-analysis and the analysis of functional components of the human genome.
Eligible Organizations
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
For more information, visit Grants.gov.