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HHS/CDC: Real-World Effectiveness of Structured Lifestyle Interventions in Preventing Type 2 Diabetes


The Centers for Disease Control and Prevention is seeking applications for a program entitled ‘Real-World Effectiveness of Structured Lifestyle Interventions in Preventing Type 2 Diabetes’.

Donor Name: Centers for Disease Control and Prevention

Country:  U.S.

State: All States

Type of Grant: Grant

Deadline (mm/dd/yyyy): 01/10/2022

Size of the Grant: $900,000

Grant Duration: 5 Years


The purpose of this Notice of Funding Opportunity Announcement (NOFO) is to create a research network consisting of multiple study sites for assessing (1) system and individual level barriers and facilitators to participation in and completion of structured lifestyle intervention (SLI) programs as implemented by the CDC National Diabetes Prevention Program (NDPP), including the Medicare Diabetes Prevention Program (MDPP) and (2) the long-term effectiveness and cost-effectiveness of NDPP/MDPP.

This NOFO has two (2) components:

  • Component A-Longitudinal cohort: The purpose of Component A is to establish a study cohort to:
    • identify system and individual level barriers and facilitators to the enrollment and completion of the NDPP/MDPP, and
    • evaluate the long term (≥5 years) effectiveness and cost-effectiveness of the NDPP/MDPP, which includes the effect of the SLI programs on:
      • reducing type 2 diabetes onset;
      • improving cardiovascular disease (CVD) risk factors including body mass index (BMI),
      • blood pressure and lipid levels, and smoking status;
      • improving health-related quality of life;
      • reducing health care services utilization and costs.
  • Component B-Coordinating Center: The purpose of component B is to provide the infrastructure for data storage (if needed), harmonizing data collection and data analysis based on a core study protocol; ensure statistical, logistics, and communications support to enhance the efficiency and productivity for component A activities.

Funding Information

  • The estimated total funding (direct and indirect) for the 5-year period of performance, September 1, 2022 to August 31, 2027, is $16,000,000. It is anticipated that 6 awards will be made under this NOFO RFA-DP-22-001.
  • Funding for the first 12-month (including both direct and indirect costs):
    • Component A: (up to 5 awards) $570,000 per award
    • Component B: (1 award) $350,000
  • Anticipated Number of Awards:
    • For Component A:
      • Award ceiling: $570,000
      • Award floor: $200,000
    • For Component B:
      • Award ceiling: $350,000
      • Award floor $200,000
  • Award Ceiling: $900,000 Per Budget Period
  • Award Floor: $200,000 Per Project Period
  • Total Period of Performance Length: 5 year(s)

Target Population

  • Component A – Longitudinal Cohort: The target population is adults (≥18 years old) in the U.S. at a high risk of developing type 2 diabetes. Applicants’ sites are expected to have access to socio-demographically disadvantaged and diverse populations
  • Component B – Coordinating Center: Applicants are expected to collaborate with recipients of component A and other partners to accomplish goals and objectives of the study. The applicant should demonstrate experience in coordination of multi-center studies, data management and innovative analysis. Applicants should demonstrate experience in working collaboratively with research partners.

Eligible Applicants

  • Eligibility Category:
    • State governments
    • County governments
    • City or township governments
    • Special district governments
    • Independent school district
    • Public and State controlled institutions of higher education
    • Native American tribal governments (Federally recognized)
    • Public housing authorities/Indian housing authorities
    • Native American tribal organizations (other than Federally recognized tribal governments)
    • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
    • Nonprofits without 501(c)(3) status with the IRS, other than institutions of higher education
    • Private institutions of higher education
    • For profit organizations other than small businesses
    • Small businesses
  • Additional Eligibility Category: The following types of Higher Education Institutions are always encouraged to apply for CDC support as Public or Private Institutions of Higher Education:
    • Hispanic-serving Institutions
    • Historically Black Colleges and Universities (HBCUs)
    • Tribally Controlled Colleges and Universities (TCCUs)
    • Alaska Native and Native Hawaiian Serving Institutions
    • Nonprofits (Other than Institutions of Higher Education)
  • Governments:
    • Eligible Agencies of the Federal Government
    • U.S. Territory or Possession
  • Other:
    • Faith-based or Community-based Organizations
    • Regional Organizations

For more information, visit Grants.gov.

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